Effects of intravenous administration of fibrinolysin (plasmin) in man.
نویسنده
چکیده
The potentiality of dissolving clots has aroused great interest in fibrinolysin (plasmin) as a therapeutic agent in thromboembolism. In this paper the effects of intravenous administration of purified fibrinolysin in man are reported, with special emphasis upon systemic toxicity and alterations in clotting factors and fibrinolytic activity. This information is necessary for the evaluation of this agent for clinical purposes.
منابع مشابه
Thrombin formation; effects of lysin (fibrinolysin, plasmin) on prothrombin, Ac-globulin and tissue thromboplastin.
In the course of a study of the blood coagulation reaction involving the use of partially purified reagents it was thought of some interest to determine effects of fibrinolytic enzyme on these isolated materials. It is well known that serum lysin (fibrinolysin, plasmin) will lyse or destroy both fibrinogen and fibrin. It may be thrombinolytic (1). Seegers and Loomis (2) have stated that it dest...
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The author has described modern thrombolytic therapy of arterial and venous thrombosis and emboli by therapeutic fibrinolysis and other drugs also methods and effects of local and parenteral application of fibrinolysin preparations, dosage, control, indications. Contraindications, side-effects and their treatment with fibrinolysin antagonists and therapy with fibrinolysin combined with anticoag...
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ورودعنوان ژورنال:
- Circulation
دوره 20 1 شماره
صفحات -
تاریخ انتشار 1959